Title of article :
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Original Research Article
Author/Authors :
3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein، نويسنده , , a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl group at the 2-position were designed based on X-ray crystallographic analysis of the complex between the isoquinolone compound and JNK3، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Yasutomi Asano, Shuji Kitamura, Taiichi Ohra, Fumio Itoh, Masahiro Kajino, Tomoko Tamura, Manami Kaneko, Shota Ikeda, Hideki Igata, Tomohiro Kawamoto, Satoshi Sogabe, Shin-ichi Matsumoto, Toshimasa Tanaka, Masashi Yamaguchi, Hiroyuki Kimura, Shoji Fukumoto
Keywords :
log D value , X-ray crystallography , In vivo efficacy , JNK , JNK inhibitor , Isoquinolone derivatives , SAR , H9c2 cell
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
