Title of article
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Original Research Article
Author/Authors
3-Metoxycarbonyl isoquinolone derivative 1 has been identified as a potent JNK inhibitor and significantly inhibited cardiac hypertrophy in a rat pressure-overload model. Herein، نويسنده , , a series of isoquinolones with an imidazolylmethyl or a pyrazolylmethyl group at the 2-position were designed based on X-ray crystallographic analysis of the complex between the isoquinolone compound and JNK3، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
16
From page
4699
To page
4714
Abstract
Yasutomi Asano, Shuji Kitamura, Taiichi Ohra, Fumio Itoh, Masahiro Kajino, Tomoko Tamura, Manami Kaneko, Shota Ikeda, Hideki Igata, Tomohiro Kawamoto, Satoshi Sogabe, Shin-ichi Matsumoto, Toshimasa Tanaka, Masashi Yamaguchi, Hiroyuki Kimura, Shoji Fukumoto
Keywords
log D value , X-ray crystallography , In vivo efficacy , JNK , JNK inhibitor , Isoquinolone derivatives , SAR , H9c2 cell
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304294
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