Title of article
Design and synthesis of benzofuranic derivatives as new ligands at the melatonin-binding site MT3 Original Research Article
Author/Authors
Mohamed Ettaoussi، نويسنده , , Basile Péres، نويسنده , , Frédérique Klupsch، نويسنده , , Philippe Delagrange، نويسنده , , Jean-A. Boutin، نويسنده , , Pierre Renard، نويسنده , , Daniel-H. Caignard، نويسنده , , Philippe Chavatte، نويسنده , , Pascal Berthelot، نويسنده , , Daniel Lesieur، نويسنده , , Saïd Yous، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
9
From page
4954
To page
4962
Abstract
Benzofuranic analogues of MCA-NAT (5-methoxycarbonylamino-N-acetyltryptamine) have been synthesized and evaluated as melatonin receptor ligands. Introduction of a methoxycarbonylamino substituent in the C-5 position of the benzofurane nucleus obtains MT3 selective ligands. This selectivity can be modulated with suitable variations of the C-5 position and the acyl group on the C-3 side chain.
Keywords
Melatonin , MCA-NAT , MT3 binding site , Binding , Benzofuranic ligands , Quinone reductase 2
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304310
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