Title of article :
Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives Original Research Article
Author/Authors :
Silvia Dei، نويسنده , , Maria Cristina Bellucci، نويسنده , , Michela Buccioni، نويسنده , , Marta Ferraroni، نويسنده , , Luca Guandalini، نويسنده , , Dina Manetti، نويسنده , , Gabriella Marucci، نويسنده , , Rosanna Matucci، نويسنده , , Marta Nesi، نويسنده , , Maria Novella Romanelli، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
Completing a long-lasting research on 1,3-oxathiolane muscarinic ligands, we have synthesized a set of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide derivatives, containing three or four stereogenic centers. In general the compounds are very potent antagonists even if, unlike the corresponding agonists, they show modest subtype selectivity.
Keywords :
3-Oxathiolane sulfoxides , 1 , functional activity , Muscarinic antagonists , Affinity
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
