Title of article
Synthesis of indirubin-N′-glycosides and their anti-proliferative activity against human cancer cell lines Original Research Article
Author/Authors
Stefanie Libnow، نويسنده , , Karen Methling، نويسنده , , Martin Hein، نويسنده , , Dirk Michalik، نويسنده , , Manuela Harms، نويسنده , , Kristian Wende، نويسنده , , Anke Flemming، نويسنده , , Martin K?ckerling، نويسنده , , Isolde Kommer, Helmut Reinke، نويسنده , , Patrick J. Bednarski، نويسنده , , Michael Lalk، نويسنده , , Peter Langer، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
14
From page
5570
To page
5583
Abstract
The first indirubin-N′-glycosides were prepared based on reactions of isatin-N′-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N′-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N′-rhamnosides.
Keywords
anti-proliferative activity , Carbohydrates , N-Heterocycles , Indirubin
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304364
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