Petiolins A–C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum Original Research ArticlePetiolins A–C, phloroglucinol derivatives from Hypericum pseudopetiolatum var. kiusianum Original Research Article

Two new phloroglucinol derivatives possessing chromane skeleton, petiolins A (1) and B (2), and a new phloroglucinol derivative containing a dihydrofuran ring, petiolin C (3), were isolated from aerial parts of Hypericum pseudopetiolatum var. kiusianum. The gross structures of 1–3 were elucidated by spectroscopic data, and the relative stereochemistry of 3 was elucidated by NOESY data. Petiolins A–C (1–3) showed modest cytotoxicity, while petiolin C (3) exhibited antifungal activity.