Pestaloficiols A–E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici Original Research Article

Pestaloficiols A–E (1–5), five new cyclopropane derivatives, have been isolated from cultures of the plant endophyte Pestalotiopsis fici. The structures of these compounds were determined by NMR spectroscopy, and the absolute configuration of 1 was assigned using the modified Mosher method. Compounds 1, 2, and 4 displayed inhibitory effects on HIV-1 replication in C8166 cells.