Title of article :
Novel aminopeptidase N inhibitors derived from 1,3,4-thiadiazole scaffold Original Research Article
Author/Authors :
GuoGang Tu، نويسنده , , Shaohua Li، نويسنده , , Huiming Huang، نويسنده , , Gang Li، نويسنده , , Fang Xiong، نويسنده , , Xi Mai، نويسنده , , and Huawei Zhu، نويسنده , , BinHai Kuang، نويسنده , , Wen Fang Xu، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Abstract :
The aminopeptidase N (APN/CD13), overexpressed in tumor cells, plays a critical role in angiogenesis. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC50 values in the micromol rang.
Keywords :
Enzyme inhibitors , Aminopeptidase N , peptidomimetics
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
