Novel antioxidant agents deriving from molecular combination of Vitamin C and NO-donor moieties Original Research Article

In this paper, we describe a new class of products in which NO-donor moieties are linked to either the 3-OH (4a–f) or 2-OH group (7a–c) of ascorbic acid (ASA). Log Ps and pKas of these products were experimentally evaluated. All the compounds were tested for their antioxidant activity on lipidic peroxidation induced by Fe3+-ADP/NADPH in lipids of microsomal membranes of rat hepatocytes. Only 3-O series displays antioxidant activity and it seems to be principally dependent on the lipophilicity. Both series trigger in vitro NO-dependent vasodilator properties.