Title of article
Synthesis and antimalarial activity of chain substituted pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 Original Research Article
Author/Authors
Thomas Kurz، نويسنده , , Katrin Schlüter، نويسنده , , Uwe Kaula، نويسنده , , B?rbel Bergmann، نويسنده , , Rolf D. Walter، نويسنده , , Detlef Geffken، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
15
From page
5121
To page
5135
Abstract
Fosmidomycin is a promising antimalarial drug candidate with a unique chemical structure and a novel mode of action. Chain substituted pivaloyloxymethyl ester derivatives of Fosmidomycin and its acetyl analogue FR900098 have been synthesized and their in vitro antimalarial activity versus the Chloroquine sensitive strain 3D7 of Plasmodium falciparum has been determined.
Keywords
Targets , Fosmidomycin , Pivaloyloxymethyl ester analogues of Fosmidomycin and FR900098 , malaria
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304517
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