Title of article
Synthesis and biological evaluation of novel PDMP analogues Original Research Article
Author/Authors
Ulrik Hillaert، نويسنده , , Swetlana Boldin-Adamsky، نويسنده , , Jef Rozenski، نويسنده , , Roger Busson، نويسنده , , Anthony H. Futerman، نويسنده , , Serge Van Calenbergh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
12
From page
5273
To page
5284
Abstract
A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from d-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward. Biological evaluation, both in vitro on rat liver Golgi fractions as well as in HEK-293 and COS-7 cells, revealed two lead compounds with comparable inhibitory potency as PDMP, which could be elaborated to more potent inhibitors.
Keywords
PDMP , Sphingolipids , C–C coupling , Glucosylceramide synthase , Inhibitor
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304531
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