Title of article :
Synthesis of 1-O-monoacyl or 12-O-monoacyl, 1-,12-O-diacyl-, and 11,12-dehydrated excisanin A 7,14-acetonides and their cytotoxic activity Original Research Article
Author/Authors :
Yutaka Aoyagi، نويسنده , , Yumi Nishioka، نويسنده , , Fukuya Tobe، نويسنده , , Tomoyo Hasuda، نويسنده , , Koichi Takeya، نويسنده , , Mingyu Gui، نويسنده , , Yong-Ri Jin، نويسنده , , Xuwen Li، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
1-O-Monoacyl, 12-O-monoacyl, 1-,12-O-diacyl, and 11,12-dehydrated excisanin A 7,14-acetonides were synthesized from excisanin A isolated from Rabdosia excisa. The structure and cytotoxic activity relationships (SAR) of the natural parent ent-kaurene diterpenes and these semisynthetic analogues were studied by using P388 murine leukemia cells.
Keywords :
Excisanin A , Semisynthesis , Ent-kaurene , SAR , Cytotoxic activity , P388 murine leukemia cells
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
