Title of article
A flexible approach for the preparation of substituted benzazepines: Application to the synthesis of tolvaptan Original Research Article
Author/Authors
Alejandro Cordero-Vargas، نويسنده , , Béatrice Quiclet-Sire، نويسنده , , Samir Z. Zard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
9
From page
6165
To page
6173
Abstract
A practical preparation of benzazepine derivatives using a series of radical and ionic reactions is reported. This approach was applied to the synthesis of tolvaptan, a very promising vasopressin V2 receptor antagonist currently in clinical trials.
Keywords
Xanthate , benzazepines , Tolvaptan , Beckmann rearrangement
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304619
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