Title of article
Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin Original Research Article
Author/Authors
Raghuram S. Tangirala، نويسنده , , Smitha Antony، نويسنده , , Keli Agama، نويسنده , , Yves Pommier، نويسنده , , Bradley D. Anderson، نويسنده , , Robert Bevins، نويسنده , , Dennis P. Curran، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
11
From page
6202
To page
6212
Abstract
Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb amide) have been prepared and tested in topoisomerase and cellular assays. The results provide insights into the structural features of the camptothecin E-ring that affect biological activity.
Keywords
Camptothecin , Topoisomerase 1 , Anti-cancer agents , Cascade radical annulation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304623
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