Title of article :
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids Original Research Article
Author/Authors :
Julieta Coro، نويسنده , , Rolando Pérez، نويسنده , , Hortensia Rodr?guez، نويسنده , , Margarita Su?rez، نويسنده , , Celeste Vega، نويسنده , , Miriam Rol?n، نويسنده , , David Montero Pereira، نويسنده , , Juan José Nogal-Ruiz، نويسنده , , Alicia G?mez-Barrio، نويسنده ,
Abstract :
Two new series of several alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids were synthesized in a two step procedure from the corresponding alkyl bis-dithiocarbamic salt intermediary. The novel compounds were evaluated for their activity in vitro against Trypanosoma cruzi strain CL (clone CL B5) and Trichomonas vaginalis strain JH 31A.
