Title of article
Search for the pharmacophore in prazosin for Transport-P Original Research Article
Author/Authors
Patricia A. Zunszain، نويسنده , , Cesare Federico، نويسنده , , Mario Sechi، نويسنده , , Saad Al-Damluji، نويسنده , , C. Robin Ganellin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
9
From page
3681
To page
3689
Abstract
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter. It is shown that the pyrimidinyl 4-amino group is critically important for binding but that the 6,7-dimethoxy and 2-furoyl groups are not essential.
Keywords
V-ATPase-linked uptake , Peptidergic neurones , Transport-P , Prazosin
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304720
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