Title of article
Mechanism of proliferation arrest of embryonic cells of Xenopus by diterpene compounds Original Research Article
Author/Authors
Tomoharu Okouchi، نويسنده , , Tetsuya Abe، نويسنده , , Shusuke Araki، نويسنده , , Shinsuke Arai، نويسنده , , Takashi Iida، نويسنده , , Li-Yan Wang، نويسنده , , Susumu Kitanaka، نويسنده , , Shohei Miyata، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
3847
To page
3851
Abstract
Three diterpene compounds isolated from the anti-cancer herbal medicine kansui, namely, kansuinin B, 20-OD-ingenol Z, and 20-OD-ingenol E, specifically inhibited the proliferation of isolated embryonic cells from Xenopus embryos. We conducted a cytologic study to determine the mechanism underlying the arrest of the cellular proliferation by these compounds. While kansuinin B and 20-OD-ingenol Z treatment decreased the cell numbers in the S phase and the M phase substages of the cell cycle, 20-OD-ingenol E inhibited mitosis.
Keywords
diterpenes , Inhibition of entrance into S phase , Proliferation arrest , Inhibition of chromatin condensation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304733
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