Title of article :
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2 Original Research Article
Author/Authors :
Guangrong Zheng، نويسنده , , Linda P. Dwoskin، نويسنده , , Agripina G. Deaciuc، نويسنده , , Jun Zhu، نويسنده , , Marlon D. Jones، نويسنده , , Peter A. Crooks، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of lobelane analogues has been synthesized and their structure–activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with Ki values ranging from 430 to 580 nM.
Keywords :
Vesicular monoamine transporter , Methamphetamine , Lobeline , Structure–activity relationships
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
