Title of article
Design, synthesis and evaluation of carbazole derivatives as PPARα/γ dual agonists and antioxidants Original Research Article
Author/Authors
Rakesh Kumar، نويسنده , , Uma Ramachandran، نويسنده , , Krishnamoorthy Srinivasan، نويسنده , , Poduri Ramarao، نويسنده , , Suryaprakash Raichur، نويسنده , , Ranjan Chakrabarti، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
12
From page
4279
To page
4290
Abstract
A series of hydroxycarbazole derivatives were synthesized and evaluated for PPARα/γ dual agonist as well as antioxidant activities. While most compounds showed good antioxidant activity, some compounds were identified as potential PPARα/γ dual agonists as well. Compounds 10a and 16 were found to be active in animal studies.
Keywords
Hypoglycemic , antioxidant , Lipid peroxidation , PPAR dual agonists , Transactivation , Hydroxycarbazoles
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304779
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