Title of article
Heteroarylisopropylamines as MAO inhibitors Original Research Article
Author/Authors
Gabriel Vallejos، نويسنده , , Angélica Fierro، نويسنده , , Marcos Caroli Rezende، نويسنده , , Silvia Sep?lveda-Boza، نويسنده , , Miguel Reyes-Parada، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
4450
To page
4457
Abstract
The in vitro monoamine oxidase inhibitory (MAOI) activities of 11 heteroarylisopropylamines vis-à-vis MAO-A and MAO-B were described and interpreted in terms of possible interactions with the enzyme active site. Molecular dynamics simulations allowed a comparison between the most active MAO-A inhibitor of the series, the 1-(2-benzofuryl)-2-aminopropane, and the specific, analogous MAO-A substrate serotonin.
Keywords
MAO inhibitors , Heteroarylisopropylamines , molecular dynamics simulation
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304797
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