Title of article
Design, modelling, synthesis and biological evaluation of peptidomimetic phosphinates as inhibitors of matrix metalloproteinases MMP-2 and MMP-8 Original Research Article
Author/Authors
Gianluca Bianchini، نويسنده , , Massimiliano Aschi، نويسنده , , Giancarlo Cavicchio، نويسنده , , Marcello Crucianelli، نويسنده , , Serena Preziuso، نويسنده , , Carlo Gallina، نويسنده , , Adele Nastari، نويسنده , , Enrico Gavuzzo، نويسنده , , Fernando Mazza، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
10
From page
4740
To page
4749
Abstract
Three novel peptidomimetic phosphinate inhibitors have been synthesized and evaluated as inhibitors of matrix metalloproteinases MMP-2 and MMP-8. Their IC50 values are in the micromolar range, and one of them showed to be the most effective inhibitor of MMP-2. The differences in binding affinities for MMP-2 and MMP-8 of the three phosphinates have been rationalized by means of modelling studies and molecular dynamics simulations.
Keywords
Matrix metalloproteinases inhibitors , Phosphinic acids , peptidomimetics , Molecular dynamics and modelling
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304826
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