Title of article :
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities Original Research Article
Author/Authors :
Fliur Macaev، نويسنده , , Ghenadie Rusu، نويسنده , , Serghei Pogrebnoi، نويسنده , , Alexandru Gudima، نويسنده , , Eugenia Stingaci، نويسنده , , Ludmila Vlad، نويسنده , , Nathaly Shvets، نويسنده , , Fatma Kandemirli، نويسنده , , Anatholy Dimoglo، نويسنده , , Robert Reynolds، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a–41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.
Keywords :
Neural network method , Anti-tubercular activity , 5-Aryl-2-thio-1 , 3 , 4-oxadiazoles , Electronic-topological method , Structure–activity relationships
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
