Author/Authors :
Kristjan S. Gudmundsson، نويسنده , , Brian A. Johns، نويسنده , , Zhicheng Wang، نويسنده , , Elizabeth M. Turner، نويسنده , , Scott H. Allen، نويسنده , , George A. Freeman، نويسنده , , F. Leslie Boyd Jr.، نويسنده , , Connie J. Sexton، نويسنده , , Dean W. Selleseth، نويسنده , , Kelly R. Moniri، نويسنده , , Katrina L. Creech، نويسنده ,
Abstract :
Herpesviruses are a significant source of human disease; amongst these herpes simplex virus 1 (HSV-1) and HSV-2 are very prevalent and cause recurrent infections. We recently identified a pyrazolo[1,5-a]pyridine scaffold that showed promising activity against HSV-1 and HSV-2 in Vero cell antiviral assays. Here, we describe the synthesis and anti-herpetic activity of several 3-pyrimidinyl-2-phenylpyrazolo[1,5-a]pyridines with differing 2-phenyl substitution patterns. Approaches to rapidly access a number of analogs with different 2-phenyl substitution patterns are outlined. Several of the compounds described have comparable activity to acyclovir against HSV-1 and HSV-2.
