Title of article :
Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs Original Research Article
Author/Authors :
Gloria V. L?pez، نويسنده , , Carlos Batthy?ny، نويسنده , , Fabiana Blanco، نويسنده , , Horacio Botti، نويسنده , , Andrés Trostchansky، نويسنده , , Eduardo Migliaro، نويسنده , , Rafael Radi، نويسنده , , Mercedes Gonzalez-Wangüemert، نويسنده , , Hugo Cerecetto، نويسنده , , Homero Rubbo، نويسنده ,
Abstract :
Synthesis and biological characterization of a series of α-tocopherol analogs with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties, and antiplatelet activity. They were also capable of preventing LDL oxidation.
Keywords :
Vitamin E , antioxidant , LDL oxidation , NO donor
