Title of article
Design, syntheses, and biological evaluations of squamostolide and its related analogs Original Research Article
Author/Authors
Cheng-Lin Lee، نويسنده , , Chi-Fong Lin، نويسنده , , Wan-Ru Lin، نويسنده , , Kun-Sheng Wang، نويسنده , , Ya-her Chang، نويسنده , , Shinne-Ren Lin، نويسنده , , Yang-Chang Wu، نويسنده , , Ming-Jung Wu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
9
From page
5864
To page
5872
Abstract
Squamostolide and its related analogs were designed and synthesized for biological evaluation. All these compounds were tested for growth inhibition activities against human tumor cell lines, in which one of the compounds showed the most potent cytotoxicity among these derivatives against a full panel of 60 human cancer cell lines. The same compound also showed G2/M phase arrest and a weak apoptotic effect during flow cytometric analysis.
Keywords
G2/M , Squamostolide , phase arrest , Apoptotic effect , Cytotoxicity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304937
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