Title of article :
Synthesis and biological evaluation of new 4β-anilino- and 4β-imido-substituted podophyllotoxin congeners Original Research Article
Author/Authors :
Ahmed Kamal، نويسنده , , N. Lakshmi Gayatri، نويسنده , , D. Rajasekhar Reddy، نويسنده , , P. S. Murali Mohan Reddy، نويسنده , , M. Arifuddin، نويسنده , , Sunanda G. Dastidar، نويسنده , , Anand K. Kondapi، نويسنده , , M. Rajkumar، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Abstract :
A series of C-4-anilino- and C-4-imido-substituted new podophyllotoxin congeners have been designed, synthesized, and evaluated for their cytotoxicity and DNA topoisomerase-II (topo-II) inhibition potential. Some of these compounds have exhibited promising in vitro anticancer and topo-II inhibition activity.
Keywords :
Podophyllotoxin , DNA topoisomerase-II , Etoposide , Substituted 2-aminobenzophenone
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
