Title of article
Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells Original Research Article
Author/Authors
Herbert Kolodziej، نويسنده , , Anne Burmeister، نويسنده , , Weronika Trun، نويسنده , , Oliver A. Radtke، نويسنده , , Albrecht F. Kiderlen، نويسنده , , Hideyuki Ito، نويسنده , , Tsutomu Hatano، نويسنده , , Takashi Yoshida، نويسنده , , Lai Yeap Foo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
7
From page
6470
To page
6476
Abstract
Some polyphenol-containing extracts (Pelargonium sidoides, Phyllanthus amarus) and representatives of simple phenols (shikimic acid 3- and 5-O-gallate), flavan-3-ols (epigallocatechin 3-gallate), proanthocyanidins (a hexamer) and hydrolysable tannins (corilagin, casuariin, geraniin) were studied for gene expressions (iNOS, IL-1, IL-10, IL-12, IL-18, TNF-α, IFN-α/γ) by RT-PCR. All extracts and compounds were capable of enhancing the iNOS and cytokine mRNA levels in parasitised cells when compared with those in non-infected conditions.
Keywords
Leishmania major , Hydrolysable tannins , Polyphenols , Inducible nitric oxide synthase , Gene expression analysis , Proanthocyanidins , Cytokines , Macrophages
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1304999
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