Oxidation of liposomal membrane suppressed by flavonoids: Quantitative structure–activity relationship Original Research Article

Antioxidant activity of the set of 12 flavonoids in heterogeneous membrane system of dioleoyl phosphatidylcholine liposomes stressed by peroxidative damage induced by 2,2′-azobis-(2-amidinopropane)hydrochloride azoiniciator and evaluated by the thiocyanate method was assessed. Antioxidant activity (pIC50) was correlated with 19 molecule parameters calculated for the minimum energy conformers of the compounds tested. The linear regression analysis revealed that the parameter of hydration energy EHYDR (R = −0.747) was the best predictor of antioxidant activity in a liposomal system.