Title of article
Triketones active against antibiotic-resistant bacteria: Synthesis, structure–activity relationships, and mode of action Original Research Article
Author/Authors
John W. van Klink، نويسنده , , Lesley Larsen، نويسنده , , Nigel B. Perry، نويسنده , , Rex T. Weavers، نويسنده , , Gregory M. Cook and Peter Dimroth، نويسنده , , Phil J. Bremer، نويسنده , , Andrew D. MacKenzie، نويسنده , , Teruo Kirikae، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
12
From page
6651
To page
6662
Abstract
A series of acylated phloroglucinols and triketones was synthesized and tested for activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE) and multi-drug-resistant Mycobacterium tuberculosis (MDR-TB). A tetra-methylated triketone with a C12 side chain was the most active compound (MIC of around 1.0 μg/ml against MRSA) and was shown to stimulate oxygen consumption by resting cell suspensions, suggesting that the primary target was the cytoplasmic membrane.
Keywords
Triketone , phloroglucinol , Stucture–activity relations , Antibacterial , Drug-resistant , membrane , Lipophilic
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2005
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305015
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