Title of article
Synthesis and biological activity of N,N-dialkylaminoalkyl-substituted bisindolyl and diphenyl pyrazolone derivatives Original Research Article
Author/Authors
New compounds، نويسنده , , structurally related to the potent protein kinase C inhibitor staurosporine، نويسنده , , with a bisindolylpyrazolone framework and substituted on the pyrazolone nitrogens with N، نويسنده , , N-dialkylaminoalkyl side chain، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
8
From page
9
To page
16
Abstract
New compounds, structurally related to the potent protein kinase C inhibitor staurosporine, with a bisindolylpyrazolone framework and substituted on the pyrazolone nitrogens with N,N-dialkylaminoalkyl side chain, were synthesized and evaluated for growth-inhibitory properties in several human cell lines. Many showed inhibition of TNF-α production in response to the tumor promotor TPA on HL-60 cells. The apoptotic activity on HeLa cells has been examined for several of these compounds.
Keywords
TNF-? , Bisindolopyrazolones , Staurosporine , PKC , apoptosis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305039
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