Title of article :
An image contrast agent selectively activated by prostate specific antigen Original Research Article
Author/Authors :
Graham B. Jones، نويسنده , , Curtis F. Crasto، نويسنده , , Jude E. Mathews، نويسنده , , Longfei Xie، نويسنده , , Miguel O. Mitchell، نويسنده , , Ahmed El-Shafey، نويسنده , , Anthony V. D’Amico، نويسنده , , Glenn J. Bubley، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen (PSA) and α-chymotrypsin, releasing free fluorophore via cleavage of a three-component system. A hexapeptide derivative showed exclusive activation by PSA and constitutes a method for tracking PSA activity in vitro.
Keywords :
Linker , Enzyme substrates , PSA , Imaging agents , Prodrugs , Hexapeptides , Coumarin , Chemical synthesis
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
