Title of article :
Synthesis of novel 5-substituted indirubins as protein kinases inhibitors Original Research Article
Author/Authors :
Anne Beauchard، نويسنده , , Yoan Ferandin، نويسنده , , Stéphane Frère، نويسنده , , Olivier Lozach، نويسنده , , Mélina Blairvacq، نويسنده , , Laurent Meijer، نويسنده , , Valérie Thiéry، نويسنده , , Thierry Besson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
In an effort to identify new pharmacological inhibitors of disease-relevant protein kinases with increased potency and selectivity, we synthesized and evaluated new 5-substituted indirubins. The effects of 34 indirubin derivatives on CDK1/cyclin B, CDK5/p25, and GSK-3, as well as on SH-SY5Y human neuroblastoma cell survival, were investigated.
Keywords :
Indirubin , Cyclin-dependent kinase , Glycogen synthase kinase-3
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
