Author/Authors :
Zhefeng Cai، نويسنده , , Jun Feng، نويسنده , , Yanshen Guo، نويسنده , , Pingping Li، نويسنده , , Zhufang Shen، نويسنده , , Fengming Chu، نويسنده , , Zongru Guo، نويسنده ,
Abstract :
A series of azaindole-α-alkyloxyphenylpropionic acid analogues was synthesized and evaluated for PPAR agonist activities. Structure–activity relationship was developed for PPARα/γ dual agonism. One of the synthesized compound 7a was identified as a potent, selective PPARα/γ dual agonist.
