Title of article :
Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors Original Research Article
Author/Authors :
Farhanullah، نويسنده , , Su Yeon Kim ، نويسنده , , Eun-Jeong Yoon، نويسنده , , Eung-Chil Choi، نويسنده , , Sunghoon Kim، نويسنده , , Taehee Kang، نويسنده , , Farhana Samrin، نويسنده , , Sadhna Puri، نويسنده , , Jeewoo Lee، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Five new structural analogues of substituted-1H-quinolinones (19, 20, 23, 24, and 26) have been synthesized and evaluated for Staphylococcus aureus methionyl-tRNA synthetase enzyme inhibitory activity. These compounds were also tested against pathogens of six S. aureus, two Enterococcus faecalis, and one Enterococcus faecium. Among all the synthesized quinolinones, compound 20 displayed significant inhibitory activities in the strains of E. faecalis and E. faecium.
Keywords :
Methionyl-tRNA synthetase inhibitor , antibacterial agent , Quinolone
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
