Author/Authors :
Vandana Srivastava، نويسنده , , Mahendra P. Darokar، نويسنده , , Atiya Fatima، نويسنده , , J.K. Kumar، نويسنده , , Chinmay Chowdhury، نويسنده , , Hari Om Saxena، نويسنده , , Gaurav R. Dwivedi، نويسنده , , Kunal Shrivastava، نويسنده , , Vivek Gupta، نويسنده , , S.K. Chattopadhyay، نويسنده , , Suaib Luqman، نويسنده , , M.M. Gupta، نويسنده , , Arvind S. Negi، نويسنده , , Suman P.S. Khanuja، نويسنده ,
Abstract :
Several diverse analogues of Oenostacin, a naturally occurring potent antibacterial phenolic acid derivative, have been synthesized. A small library with more than forty analogues having different aromatic rings and varied side chains has been achieved through solution phase synthesis. Some of these analogues, that is, 22, 23 and 42, possessed potent antibacterial activities against Staphylococcus epidermidis and Staphylococcus aureus having EC50 ranging from 0.49 to 0.67 μM as compared to Oenostacin (EC50 = 0.12 μM).
Keywords :
Oenostacin , Antibacterial , Analogue synthesis , Phenolic acids
