Title of article
Design, synthesis, and SAR analysis of novel selective σ1 ligands Original Research Article
Author/Authors
Simona Collina، نويسنده , , Guya Loddo، نويسنده , , Mariangela Urbano، نويسنده , , Laura Linati، نويسنده , , Athos Callegari، نويسنده , , Francesco Ortuso، نويسنده , , Stefano Alcaro، نويسنده , , Christian Laggner، نويسنده , , Thierry Langer، نويسنده , , Orazio Prezzavento، نويسنده , , Giuseppe Ronsisvalle، نويسنده , , Ornella Azzolina، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
13
From page
771
To page
783
Abstract
A new series of arylalkyl- and alkenylamines was designed, synthesized, and evaluated for binding to σ1 and σ2 receptors. Many compounds exhibited nanomolar affinity for σ1 subtype receptor with good selectivity over σ2. A molecular modeling study was conducted in order to rationalize the experimental data, and the structure-receptor affinities are discussed.
Keywords
Molecular modeling , SAR studies , Arylalkylamines , Sigma receptors
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305321
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