Title of article
Enantioselective synthesis and antiviral activity of purine and pyrimidine cyclopentenyl C-nucleosides Original Research Article
Author/Authors
Jagadeeshwar R. Rao، نويسنده , , Raymond F. Schinazi، نويسنده , , Chung K. Chu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
839
To page
846
Abstract
The enantiomerically pure carbocyclic purine and pyrimidine C-nucleosides 1–4 were synthesized via the key intermediate, 2,3-(isopropylidenedioxy)-4-(trityloxymethyl)-4-cyclopenten-1-ol (5), which was prepared from d-ribose in eight steps. Synthesized compounds were evaluated as potential antiviral agents against HIV, SARSCoV, Punta Toro, West Nile, and Cowpox viruses. However, only 9-deazaneplanocin A (1) exhibited moderate anti-HIV activity.
Keywords
Carbocyclic C-nucleosides , Enantioselective synthesis , Antiviral activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305327
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