Author/Authors :
Takashi Kondo، نويسنده , , Takahiro Nekado، نويسنده , , Isamu Sugimoto، نويسنده , , Kenya Ochi، نويسنده , , Shigeyuki Takai، نويسنده , , Atsushi Kinoshita، نويسنده , , Yohei Tajima، نويسنده , , SUSUMU YAMAMOTO، نويسنده , , Kazuhito Kawabata، نويسنده , , Hisao Nakai، نويسنده , , Masaaki Toda، نويسنده ,
Abstract :
A series of 5β-methylprolyl-2-cyanopyrrolidine analogs were synthesized and evaluated as DPP-IV inhibitors, and the duration of their ex vivo activity was assessed. Comparison of their potency and duration of action was done among three different species. The mode of binding was investigated, and the effect on the plasma glucose level was evaluated. Structure–activity relationships are also presented.
