Title of article
Synthesis and biological evaluation of phosphonated carbocyclic 2′-oxa-3′-aza-nucleosides Original Research Article
Author/Authors
Ugo Chiacchio، نويسنده , , Daniela Iannazzo، نويسنده , , Anna Piperno، نويسنده , , Roberto Romeo، نويسنده , , Giovanni Romeo، نويسنده , , Antonio Rescifina، نويسنده , , Monica Saglimbeni، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
955
To page
959
Abstract
The synthesis of carbocyclic 2′-oxa-3′-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed.
Keywords
1 , 3-dipolar cycloaddition , modified nucleosides , Phosphonated nucleosides , Antiviral activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305476
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