Title of article :
Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid Original Research Article
Author/Authors :
Yoshiyuki Hari، نويسنده , , Satoshi Obika، نويسنده , , Ryo Ohnishi، نويسنده , , Ken Eguchi، نويسنده , , Tomohisa Osaki، نويسنده , , Hirofumi Ohishi، نويسنده , , Takeshi Imanishi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
A novel bridged nucleic acid (BNA) analogue, 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNACOC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNACOC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.
Keywords :
Bridged nucleic acids , Nucleosides , conformation , Oligonucleotides
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
