Title of article
Synthesis and properties of 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid Original Research Article
Author/Authors
Yoshiyuki Hari، نويسنده , , Satoshi Obika، نويسنده , , Ryo Ohnishi، نويسنده , , Ken Eguchi، نويسنده , , Tomohisa Osaki، نويسنده , , Hirofumi Ohishi، نويسنده , , Takeshi Imanishi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
10
From page
1029
To page
1038
Abstract
A novel bridged nucleic acid (BNA) analogue, 2′-O,4′-C-methyleneoxymethylene bridged nucleic acid (2′,4′-BNACOC), was synthesized and incorporated into oligonucleotides. The 2′,4′-BNACOC modified oligonucleotides showed high binding affinity with an RNA complement and significant enzymatic stability against snake venom phosphodiesterase.
Keywords
Bridged nucleic acids , Nucleosides , conformation , Oligonucleotides
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305482
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