Title of article
Combination of porphyrins and DNA-alkylation agents: Synthesis and tumor cell apoptosis induction Original Research Article
Author/Authors
Hanping He، نويسنده , , Yan Zhou، نويسنده , , Feng Liang، نويسنده , , Dongqing Li، نويسنده , , Juanjuan Wu، نويسنده , , Li Yang، نويسنده , , Xiang Zhou، نويسنده , , Xiaolian Zhang، نويسنده , , Xiaoping Cao، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
10
From page
1068
To page
1077
Abstract
A series of porphyrin–DNA cross-linking conjugates were synthesized. Their cytotoxicities to tumor cells were tested using MTT assays first. Then, HeLa cell apoptosis induced by these cationic porphyrins under the light was examined by laser confocal microscopy, flow cytometric analysis, and further confirmed by observing the morphological changes and DNA fragmentation mainly.
Keywords
Porphyrin , apoptosis , Morphological change
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305487
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