Title of article :
Guanaconetins, new antitumoral acetogenins, mitochondrial complex I and tumor cell growth inhibitors Original Research Article
Author/Authors :
Nadia Chahboune، نويسنده , , Isabel Barrachina، نويسنده , , Inmaculada ROYO، نويسنده , , Vanessa Romero، نويسنده , , Jairo Saez، نويسنده , , José R. Tormo، نويسنده , , Nuria De Pedro، نويسنده , , Ernesto Estornell، نويسنده , , M. Carmen Zafra-polo، نويسنده , , Fernando PELAEZ، نويسنده , , Diego Cortes، نويسنده ,
Abstract :
The antitumoral activity of a series of acetylated bis-tetrahydrofuranic acetogenins with a threo/trans/threo/trans/erythro relative configuration was characterized by four new natural and two semisynthetic, 15,24,30-trioxygenated acetogenins that were found to inhibit mitochondrial complex I enzyme as well as growth of several tumor cell lines. Placement of acetyl groups along the alkyl chain modulated the potency of the bis-tetrahydrofuranic acetogenins and could be important for future utilization of these compounds as chemotherapeutic agents.
Keywords :
Complex I inhibitors , Acetylated annonaceous acetogenins , Structure–activity relationship , Growth tumor cell inhibitors
