Title of article
Structure–activity relationship study of homoallylamines and related derivatives acting as antifungal agents Original Research Article
Author/Authors
Fernando D. Suvire، نويسنده , , Maximiliano Sortino، نويسنده , , Vladimir V. Kouznetsov، نويسنده , , Leonor Y. Vargas M، نويسنده , , Susana A. Zacchino، نويسنده , , Uriel Mora Cruz، نويسنده , , Ricardo D. Enriz، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
12
From page
1851
To page
1862
Abstract
The synthesis, in vitro evaluation, and structure–activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
Keywords
Antifungal activity , Homoallylamines , SAR , Synthesis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305564
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