Title of article
Novel fluorescent markers for hypoxic cells of naphthalimides with two heterocyclic side chains for bioreductive binding Original Research Article
Author/Authors
Yan Liu، نويسنده , , Yufang Xu، نويسنده , , Xuhong Qian، نويسنده , , Jianwen Liu، نويسنده , , Liyun Shen، نويسنده , , Junhui Li، نويسنده , , Yuanxing Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
7
From page
2935
To page
2941
Abstract
Novel naphthalimides with two heterocyclic side chains of 2-nitroimidazole for bioreductive binding were designed, synthesized, and used as fluorescent markers for hypoxic cells. Their evaluation for imaging tumor hypoxia was carried out in V79 cells, CHO cells, and 95D cells in vitro by using fluorescence scan ascent. A2 and A4 showed a very large differential fluorescence between hypoxic and oxic cells (V79 cells) in vitro and are promising candidate markers for hypoxic cells.
Keywords
Bioreductive binding , 2-nitroimidazole , Fluorescent markers , Hypoxic cells , naphthalimides
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2006
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305663
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