Title of article
In vitro efficiency of new acridyl derivatives against Plasmodium falciparum Original Research Article
Author/Authors
Lucie Guetzoyan، نويسنده , , Florence Ramiandrasoa، نويسنده , , Hélène Dorizon، نويسنده , , Christine Desprez، نويسنده , , Alexandre Bridoux، نويسنده , , Christophe Rogier، نويسنده , , Bruno Pradines، نويسنده , , Martine Perrée-Fauvet، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
12
From page
3278
To page
3289
Abstract
A series of new 9-substituted acridyl derivatives were synthesized and their in vitro antimalarial activity was evaluated against one chloroquine-sensitive strain (3D7) and three chloroquine-resistant strains [W2 (Indochina), Bre1 (Brazil) and FCR3 (Gambia)] of Plasmodium falciparum. Some compounds inhibit the growth of malarial parasite with IC50 ⩽ 0.20 μM.
Keywords
Plasmodium falciparum , Peptidic synthesis , antimalarial , aminoacridine
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305748
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