Title of article
Molecular design, chemical synthesis, and biological evaluation of ‘4-1’ pentacyclic aryl/heteroaryl-imidazonaphthalimides Original Research Article
Author/Authors
Feng Li، نويسنده , , Jingnan Cui، نويسنده , , Lianying Guo، نويسنده , , Xuhong Qian، نويسنده , , Weimin Ren، نويسنده , , Kewei Wang، نويسنده , , Fengyu Liu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
8
From page
5114
To page
5121
Abstract
A novel series of ‘4-1’ pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.
Keywords
Aryl/heteroaryl-imidazonaphthalimides , ‘4-1’ Pentacyclic DNA-intercalating agents
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305916
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