Title of article
Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines Original Research Article
Author/Authors
Mark A. Elban، نويسنده , , Jean C. Chapuis، نويسنده , , Mei Li، نويسنده , , Sidney M. Hecht and Stewart Shuman، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
6119
To page
6125
Abstract
Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.
Keywords
Cepharadiones A and B , Oxoaporphines , Suzuki coupling , Cytotoxicity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1305996
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