Title of article
Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives Original Research Article
Author/Authors
Gang Liu، نويسنده , , Deyu Hu، نويسنده , , Linhong Jin، نويسنده , , Bao-An Song، نويسنده , , Song Yang، نويسنده , , Ping-Shen Liu، نويسنده , , Pinaki S. Bhadury، نويسنده , , Yao Ma، نويسنده , , Hui Luo، نويسنده , , Xian Zhou، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
10
From page
6608
To page
6617
Abstract
A series of 4-aminoquinazoline derivatives is prepared by the nucleophilic substitution reaction of 6,7,8-trimethoxy-4-chloroquinazoline and aryl amine. The structures of the compounds are confirmed by elemental analysis, IR, and 1H NMR spectral data. The compounds are also evaluated for their ability to inhibit tumor cells PC3, A431, Bcap-37, and BGC823 by MTT assays. Among them, 6b and 6e are found as potent inhibitors, with IC50 values ranging from 5.8 to 9.8 μM, in vitro assay.
Keywords
Quinazoline , Amino moiety , Synthesis , Anticancer activities , Gallic acid
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306042
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