Title of article
Synthesis of disulfide esters of dialkylaminocarbothioic acid as potent, non-detergent spermicidal agents Original Research Article
Author/Authors
Anil Kumar Dwivedi، نويسنده , , Vishnu Lal Sharma، نويسنده , , Niharika Kumaria، نويسنده , , S.T.V.S. Kiran Kumar، نويسنده , , Pradeep Kumar Srivastava، نويسنده , , Abdul Haq Ansari، نويسنده , , Jagdamba Prasad Maikhuri، نويسنده , , Enrico Pontelli and Gopal Gupta ، نويسنده , , Janak Dulari Dhar، نويسنده , , Raja Roy، نويسنده , , Bhawani Shankar Joshi، نويسنده , , Praveen Kumar Shukla، نويسنده , , Manish Kumar، نويسنده , , Satyawan Singh، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
6642
To page
6648
Abstract
S,S′-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14–31) were prepared and evaluated for the spermicidal activity and antifungal activity. Dialkyldithiocarbamates (1–5) were reacted with epichlorohydrin to give 1-dialkylaminocarbothioic acid S-[(2,3-epithio)propyl]ester (7–11), these on further reaction with a secondary amine gave S,S′-[disulfanediylbis(dialkylaminopropane-2,1-diyl)]bis- (dialkylaminothiocarbamate) (14–31). Some of these compounds (16, 19–21, 23, 30, 31) were found to be very potent spermicidal agents with marginal antifungal activity. Two compounds (20, 21) were 25 times more active than nonoxynol-9 (N-9), the spermicide currently in the market.
Keywords
Antifungal activity , Disulfide esters , Dialkylaminocarbothioic acid , Non-detergent spermicide , spermicidal activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2007
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306045
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