Title of article
Design, synthesis and preliminary pharmacological evaluation of new analogues of DM232 (unifiram) and DM235 (sunifiram) as cognition modulators Original Research Article
Author/Authors
Elisabetta Martini، نويسنده , , Monica Norcini، نويسنده , , Carla Ghelardini، نويسنده , , Dina Manetti، نويسنده , , Silvia Dei، نويسنده , , Luca Guandalini، نويسنده , , Michele Melchiorre، نويسنده , , Simona Pagella، نويسنده , , Serena Scapecchi، نويسنده , , Elisabetta Teodori، نويسنده , , Maria Novella Romanelli، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
9
From page
10034
To page
10042
Abstract
A series of amides, structurally related to DM232 (unifiram) and DM235 (sunifiram), characterized by a 1,2,3,4-tetrahydropyrazino[2,1-a]isoindol-6(2H)-one, 1,4-diamino-cyclohexane or 1,4-diaminobenzene ring, have been synthesized and tested for cognition-enhancing activity in the mouse passive-avoidance test. Some of the compounds display good antiamnesic and procognitive activity, with higher potency than piracetam, while some cyclohexane derivatives are endowed with amnesia inducing properties.
Keywords
Cognition-enhancers , Mouse passive-avoidance test , Cognition-modulators , Sunifiram
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306105
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