Author/Authors :
Andreas J. Steiner، نويسنده , , Georg Schitter، نويسنده , , Arnold E. Stütz، نويسنده , , Tanja M. Wrodnigg، نويسنده , , Chris A. Tarling، نويسنده , , Stephen G. Withers and Pedro M. Alzari، نويسنده , , Katrin Fantur، نويسنده , , Don Mahuran، نويسنده , , Eduard Paschke، نويسنده , , Michael Tropak، نويسنده ,
Abstract :
Cyclization by double reductive amination of l-arabino-hexos-5-ulose with suitably protected d- as well as l-lysine derivatives provided 1-deoxygalactonojirimycin lysine hybrids without any observable epimer formation at C-5. Modifications on the lysine moiety by acylation gave access to lipophilic derivatives which exhibited excellent d-galactosidase inhibitory activities.
Keywords :
Benzimidazole , Angiotensin II antagonists , Sulfamoyl , Binding profile , Antihypertensive
